R&d Specialist for Metabolic Research in

il y a 2 semaines

Luxembourg Université du Luxembourg Temps plein

The **Luxembourg Centre for Systems Biomedicine (LCSB)** is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_ - with a focus on neurodegenerative processes. The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists, and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary and together we contribute to science and society.

**Your Role...**:

- Develop isothermal titration calorimetry (ITC)-based methods to study biomolecular interactions and enzyme kinetics
- Develop targeted mass spectrometry-based metabolomics methods for metabolites of interest
- Perform targeted and untargeted mass spectrometry-based metabolomics analyses in biological samples
- Perform metabolomics data analysis
- Contribute to chemical identification of relevant unknown peaks using cheminformatics approaches and final validation using targeted methods
- Set up and perform metabolic enzyme assays using various techniques
- Design and produce recombinant plasmids for various purposes (e.g. protein overexpression, transgenesis)
- Perform analysis of all generated experimental data, including statistics
- Use modern data management and establish precise project documentation
- Work in a collaborative environment, also with different service-based core platforms (e.g. sequencing, metabolomics facilities)
- Independent drafting of project reports and grant proposals
- Contributing to writing manuscripts for publication in high-quality journals
- Presentation of research findings at internal, national, and international scientific meetings

**What we expect from you**:

- Master’s degree in analytical chemistry, biochemistry, molecular biology, or another similar life science-related discipline
- Experience with and strong background in metabolic biochemistry, enzymology, and molecular biology
- Experience with biophysics approaches and specifically isothermal titration calorimetry
- Experience in mass spectrometry, preferably in a metabolomics setting
- Keen interest in investigating the molecular basis of rare neurological/neurometabolic diseases
- Strong motivation to contribute specific parts to larger projects
- Strong computational skills, including programming, will be considered as an important asset
- Solid bioinformatic and biostatistics skills
- Excellent organizational and management skills
- Excellent communication skills
- Fluency in oral and written English is essential

**Here’s what awaits you at the LCSB...**:

- **Excellent work environment** with state-of-the-art infrastructure, laboratory and administrative support
- **Truly connected. **We work together with hospitals and research institutes on a national and international level as well as industrial partners. Connection between science and society is very important to us. From our school lab - the Scienteens Lab - to the different outreach activities and collaborative partnerships with patient associations, we love to listen to society’s needs and share our passion for science
- **Be part of a multicultural team. **At the LCSB we have more than 50 nationalities. Throughout the year, we organise team-building events, networking activities and more

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