Postdoc: infective competence of the human microbiome
il y a 4 semaines
About us...
The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer's and Parkinson's disease and their contributing factors.
The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary and together we contribute to science and society.
The University of Luxembourg has the following vacancy at the Luxembourg Centre for Systems Biomedicine (LCSB):Postdoctoral researcher focusing on the infective competence of the human microbiome in health and disease.
AREA: Computational and experimental study of gut microbiome-borne pathogenicity.
DESCRIPTION:
The Systems Ecology group at the LCSB is further expanding its research efforts on microbiomes and has an immediate opening for a highly motivated and talented postdoctoral researcher (entry- to advanced-level position) to work on the resolution of the role of microbiome-borne virulence factors, antibiotic resistance genes, and biosynthetic gene clusters in human health and disease using computational biology approaches.
The human microbiome represents a reservoir of pathogen-associated genes, more specifically virulence factors, including toxins, antimicrobial resistance genes and biosynthetic gene clusters. Studies focusing on the role of these infection-mediating genes are typically limited to specific pathogenic taxa and seldomly consider the overall infective competence represented by them in the context of the microbiome. Here, using a triptych approach leveraging in silico, in vitro and in vivo methods, we aim to specifically and systematically characterise and validate microbiome-borne VFs, implicated in human diseases, with a particular focus on their cytotoxicity and immunogenicity.
To achieve these aims, this project is a close collaboration between the Systems Ecology group (head: Paul Wilmes, Luxembourg, the Molecular Disease Mechanisms group (co-head: Elisabeth Letellier, Luxembourg), the EMBL-EBI's Microbiome Informatics team (head: Robert Finn, United Kingdom), and the Protein Expression and Purification Core Facility (head: Kim Remans, Germany). The current position will build on the computational solutions developed by the project partners, notably PathoFact and MGnify.
Your Role...
You will expand the the functionality of PathoFact through additional contextual information and a broader set of annotations and employ additional ML/AI-based methods to improve the identification of virulence factors as well as antibiotic resistance genes and biosynthetic gene clusters. You will, in collaboration with our project partner at EMBL-EBI, hosting and maintaining the MGnify pipeline, mature the software stack to enable easy deployment within MGnify pipelines. This will lead to computational solutions which will be applied to relevant datasets to establish a baseline of the prevalence and abundance of these microbiome-derived genes and to compare these aspects, thereby resolving the microbiome-borne pathogenic potential in a variety of diseases. You will closely interact with project partners at the University of Luxembourg and EMBL to advance from the identification of new virulence factors in silico to the assessment of the pathogenicity of these virulence factors in vitro and in vivo. You will furthermore support data management and analysis on servers of the group as well as the University of Luxembourg's High Performance Computing Cluster.
Important technical competencies and tasks include, but are not limited to:
- Experienced in sequence-based and/or structure-based functional annotation of microbial genomes, including also metagenome-assembled genomes
- Prior work with virulence factors (in silico/in vitro) is considered an asset
- Implementation of reproducible computational workflows (using snakemake, nextflow, etc.)
- Collaborative code development using Git and GitHub/GitLab
- End-to-end processing (QC, preprocessing, processing, data analysis) of at least one of the following data types: metagenomics, metatranscriptomics, metaproteomics, metametabolomics, is considered an asset
- Familiarity with UNIX/LINUX-based operating systems and shared compute infrastructure
What we expect from you...
- A PhD in Biomedical Sciences, Biochemistry, Bioinformatics, Analytical Chemistry, Microbial Ecology, or related disciplines
- Dry-laboratory experience
- Experience in translating dry-lab experience to wet-lab experiments is considered an important asset
- Previous experience in bioinformatic analysis of mixed microbial communities or Systems Biology datasets in at least one computer programming or scripting language (Python, R, Ruby, etc.) will be considered assets
- A good working knowledge of basic statistical concepts
- Team player
- Highly reliable and precise work style
- Great organizational skills and willingness to work independently in phases of potentially little guidance from supervisor
- Prior supervision activities, e.g., undergraduate or graduate students, will be considered an asset
- Excellent working knowledge of English
Here's what awaits you at the LCSB...
- Excellent work environment with state-of-the-art infrastructure, laboratory and administrative support
- Truly connected. We work together with hospitals and research institutes on a national and international level as well as industrial partners. Connection between science and society is very important to us. From our school lab - the Scienteens Lab - to the different outreach activities and collaborative partnerships with patient associations, we love to listen to society's needs and share our passion for science
- Be part of a multicultural team. At the LCSB we have more than 50 nationalities. Throughout the year, we organise team-building events, networking activities and more
Find out more about us
How to apply...
Applications should be submitted online and include:
- A detailed curriculum vitae
- List of publications, if applicable
- Cover letter indicating your motivation for this position, relevant past experience and future interests
- Name and addresses of two referees
Early application is highly encouraged, as the applications will be processed upon reception. Please apply formally through the HR system. Applications by email will not be considered.
The University of Luxembourg embraces inclusion and diversity as key values. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff.
General information:
- Contract type: Fixed Term Contract 24 Month (may be extended up to 5 years)
- Start date: June 2024
- Work hours: Full Time 40.0 Hours per Week
- Location: Belval
- Job reference: UOL06274
The yearly gross salary for every Postdoctoral Researcher at the UL is EUR full time)
-
Postdoc Focusing On The Role of Infective
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_. We focus on neurodegenerative processes and are especially interested in Alzheimer's and...
-
R&d Focusing On Supporting The Application and
il y a 2 semaines
Luxembourg, Luxembourg University of Luxembourg Temps pleinAbout us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_. We focus on neurodegenerative processes and are especially interested in...
-
R&d Focusing On Supporting The Application and
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_. We focus on neurodegenerative processes and are especially interested in Alzheimer's and...
-
Postdoc On Dynamics of Quantum Systems
il y a 2 semaines
Luxembourg, Luxembourg University of Luxembourg Temps pleinThe University | About us...Your Role...The postdoc fellow will be working on dynamics of non-Hermitian quantum systems.The applicant should be a creative and motivated researcher with knowledge on one or all of the following: Manybody physics Quantum optics Quantum dynamics Stochastic processesYour possible role: develop and characterize master equation for...
-
Head of Human Resources
il y a 2 semaines
Luxembourg, Luxembourg Innpact S.A. Temps pleinInnpact is the first certified B Corporation in Luxembourg. We recruit people who believe in finance as a force for good to support sustainable impact finance initiatives aiming at solving social and environmental issues. Our talents are passionate about impact finance and have very high ethical standards.Innpact provides specialized consulting services and...
-
Postdoc Position On Quantum Skyrmions
il y a 2 semaines
Luxembourg, Luxembourg University of Luxembourg Temps pleinThe University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...
-
Research Support Technician Focusing On Supporting
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_. We focus on neurodegenerative processes and are especially interested in Alzheimer's and...
-
Postdoc (80%): Mitigation of Stormwater Runoff
il y a 2 semaines
Luxembourg, Luxembourg Springer Nature Temps pleinPostdoc (80%): Mitigation of Stormwater Runoff:EmployerUniversity of LuxembourgLocationLuxembourgSalaryNegotiableClosing date13 May 2024Discipline Chemistry, Engineering Job Type Postdoctoral Employment - Hours Part time Duration Fixed term Qualification PhD Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob...
-
Postdoc in Physics
Il y a 2 mois
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe University | About us...In the framework of an FNR funded project we will investigate the fundamental limitations of chalcopyrite thin film solar cells in order to improve their efficiency. Thin film solar cells provide the electricity source with the lowest greenhouse gas emissions. Your Role...The postdoc will be a member of the Department of Physics...
-
Postdoc Position in Oral History
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...
-
Postdoc Position in Oral History
il y a 4 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...
-
Phd Student in Human-centered Design of
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_. We focus on neurodegenerative processes and are especially interested in Alzheimer's and...
-
Human Resources Officer
il y a 2 semaines
Luxembourg, Luxembourg Mitsubishi UFJ Investor Services Banking Luxembourg S.A. Temps pleinMitsubishi UFJ Investor Services and Banking (Luxembourg) S.A. (MIBL) is a Bank incorporated in Luxembourg and is fully owned by Mitsubishi UFJ Trust and Banking Corporation, member of the Mitsubishi UFJ Financial Group, one of the largest financial groups worldwide. MIBL provides a wide range of financial services to institutional investors including...
-
Human Resources Lawyer
il y a 2 semaines
Luxembourg, Luxembourg European Investment Bank Temps pleinThe EIB, the European Union's bank, is seeking to recruit for its Human Resources Directorate (HR), HR Strategy and Governance Department (HRS&G), Employee Relations & Wellbeing Division (ER&W), HR Disciplinary and Review Procedures Unit (DRP) at its headquarters in Luxembourg, a (Associate) Human Resources Lawyer*.**- _internal benchmark: (Associate)...
-
Postdoc Soil Monitoring Using Lora
il y a 2 semaines
Luxembourg, Luxembourg Springer Nature Temps pleinPostdoc Soil Monitoring using LoRa: Employer Interdisciplinary Centre for Security, Reliability and Trust (SnT), University of Luxembourg Location Luxembourg Salary Negotiable Closing date 4 Jun 2024 Discipline Computing, Engineering Job Type Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You need to sign in...
-
Human Resources Administration Manager
il y a 2 semaines
Luxembourg, Luxembourg Mizuho Trust & Banking Luxembourg S.A. Temps pleinJob Position - UndeterminedJob Type - Full timeLocation - LuxembourgMizuho Trust & Banking (Luxembourg) S.A.is part of the Mizuho Financial Group, a Holding Company, which is one of the world's largest financial group.Within the framework of our Luxembourg based activities, we are recruiting a:Human Resources Administration Manager (M/F)to strengthen the...
-
Senior Leadership Consultant
il y a 2 semaines
Luxembourg, Luxembourg Human Edge Temps pleinUnternehmensbeschreibungRevolutionieren Sie die Human Resources Branche und arbeiten Sie mit einem der besten Schweizer Human Resources StartupsBei Human Edge leben wir die agile Denkweise und streben danach unsere Arbeitsweise kontinuierlich zu verbessern. Wir sind leidenschaftlich in all unseren Aktivitäten und schaffen ein Umfeld, das Innovation,...
-
Human Resources Coordinator
il y a 2 semaines
Luxembourg, Luxembourg Aral Luxembourg S.A. Temps pleinAral, a subsidiary of the BP Group, operates the largest network of service stations in Luxembourg and supplies thousands of customers every day. Aral is the market leader in the Luxembourg service station market. Not only do we rely on the excellent quality of our products and services, but we are also preparing today for the demands that the market and our...
-
Postdoc Position in Contemporary History
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research in the areas of Computer...
-
Human Resources Manager
il y a 2 semaines
Luxembourg, Luxembourg Austin Bright Temps pleinIntroduction:You have behind you many years in the human resources sector and wish to evolve in a stable structure and a healthy atmosphere?So our client company will allow you to give another look to your career.You will work in brand new offices and in a family-team company, it will allow you to grow in a nice international environment.Responsibilities:HR...
