Postdoc Focusing On The Role of Infective

il y a 2 semaines

Luxembourg, Luxembourg Université du Luxembourg Temps plein
The
Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg.

We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_.

We focus on neurodegenerative processes and are especially interested in Alzheimer's and Parkinson's disease and their contributing factors.


The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB.

We excel because we are truly interdisciplinary and together we contribute to science and society.


The University of Luxembourg has the following vacancy at the Luxembourg Centre for Systems Biomedicine (LCSB)
:Postdoctoral researcher focusing on the infective competence of the human microbiome in health and disease.



AREA:

Computational and experimental study of gut microbiome-borne pathogenicity.

DESCRIPTION:

The Systems Ecology group at the LCSB is further expanding its research efforts on microbiomes and has an immediate opening for a highly motivated and talented postdoctoral researcher (entry
- to advanced-level position) to work on the resolution of the role of microbiome-borne virulence factors, antibiotic resistance genes, and biosynthetic gene clusters in human health and disease using computational biology approaches.


The human microbiome represents a reservoir of pathogen-associated genes, more specifically virulence factors, including toxins, antimicrobial resistance genes and biosynthetic gene clusters.

Studies focusing on the role of these infection-mediating genes are typically limited to specific pathogenic taxa and seldomly consider the overall infective competence represented by them in the context of the microbiome.

Here, using a triptych approach leveraging in silico, in vitro and in vivo methods, we aim to specifically and systematically characterise and validate microbiome-borne VFs, implicated in human diseases, with a particular focus on their cytotoxicity and immunogenicity.


To achieve these aims, this project is a close collaboration between the Systems Ecology group (head: Paul Wilmes, Luxembourg, the Molecular Disease Mechanisms group (co-head: Elisabeth Letellier, Luxembourg), the EMBL-EBI's Microbiome Informatics team (head: Robert Finn, United Kingdom), and the Protein Expression and Purification Core Facility (head: Kim Remans, Germany).

The current position will build on the computational solutions developed by the project partners, notably PathoFact and MGnify.

Your Role
:


You will expand the the functionality of PathoFact through additional contextual information and a broader set of annotations and employ additional ML/AI-based methods to improve the identification of virulence factors as well as antibiotic resistance genes and biosynthetic gene clusters.

You will, in collaboration with our project partner at EMBL-EBI, hosting and maintaining the MGnify pipeline, mature the software stack to enable easy deployment within MGnify pipelines.

This will lead to computational solutions which will be applied to relevant datasets to establish a baseline of the prevalence and abundance of these microbiome-derived genes and to compare these aspects, thereby resolving the microbiome-borne pathogenic potential in a variety of diseases.

You will closely interact with project partners at the University of Luxembourg and EMBL to advance from the identification of new virulence factors in silico to the assessment of the pathogenicity of these virulence factors in vitro and in vivo.

You will furthermore support data management and analysis on servers of the group as well as the University of Luxembourg's High Performance Computing Cluster.

Important technical competencies and tasks include, but are not limited to:

  • Experienced in sequence-based and/or structure-based functional annotation of microbial genomes, including also metagenome-assembled genomes
  • Prior work with virulence factors (in silico/in vitro) is considered an asset
  • Implementation of reproducible computational workflows (using snakemake, nextflow, etc.)
  • Collaborative code development using Git and GitHub/GitLab
  • Endtoend processing (QC, preprocessing, processing, data analysis) of at least one of the following data types: metagenomics, metatranscriptomics, metaproteomics, metametabolomics, is considered an asset
  • Familiarity with UNIX/LINUXbased operating systems and shared compute infrastructure

What we expect from you:

  • A PhD in Biomedical Sciences, Biochemistry, Bioinformatics, Analytical Chemistry, Microbial Ecology, or related disciplines
  • Drylaboratory experience
  • Experience in translating drylab experience to wetlab experiments is considered an important asset
  • Previous experience in bioinformatic analysis of mixed microbial communities or Sys

  • Postdoc: infective competence of the human microbiome

    il y a 4 semaines

    Luxembourg, Luxembourg Université du Luxembourg Temps plein

    About us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in...

  • R&d Focusing On Supporting The Application and

    il y a 2 semaines

    Luxembourg, Luxembourg University of Luxembourg Temps plein

    About us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_. We focus on neurodegenerative processes and are especially interested in...

  • Postdoc On Dynamics of Quantum Systems

    il y a 2 semaines

    Luxembourg, Luxembourg University of Luxembourg Temps plein

    The University | About us...Your Role...The postdoc fellow will be working on dynamics of non-Hermitian quantum systems.The applicant should be a creative and motivated researcher with knowledge on one or all of the following: Manybody physics Quantum optics Quantum dynamics Stochastic processesYour possible role: develop and characterize master equation for...

  • R&d Focusing On Supporting The Application and

    il y a 2 semaines

    Luxembourg, Luxembourg Université du Luxembourg Temps plein

    The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_. We focus on neurodegenerative processes and are especially interested in Alzheimer's and...

  • Postdoc Position On Quantum Skyrmions

    il y a 2 semaines

    Luxembourg, Luxembourg University of Luxembourg Temps plein

    The University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...

  • Postdoc in Physics

    Il y a 2 mois

    Luxembourg, Luxembourg Université du Luxembourg Temps plein

    The University | About us...In the framework of an FNR funded project we will investigate the fundamental limitations of chalcopyrite thin film solar cells in order to improve their efficiency. Thin film solar cells provide the electricity source with the lowest greenhouse gas emissions. Your Role...The postdoc will be a member of the Department of Physics...

  • Postdoc Position in Oral History

    il y a 2 semaines

    Luxembourg, Luxembourg Université du Luxembourg Temps plein

    The University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...

  • Postdoc Position in Oral History

    il y a 4 semaines

    Luxembourg, Luxembourg Université du Luxembourg Temps plein

    The University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...

  • Postdoc Soil Monitoring Using Lora

    il y a 2 semaines

    Luxembourg, Luxembourg Springer Nature Temps plein

    Postdoc Soil Monitoring using LoRa: Employer Interdisciplinary Centre for Security, Reliability and Trust (SnT), University of Luxembourg Location Luxembourg Salary Negotiable Closing date 4 Jun 2024 Discipline Computing, Engineering Job Type Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You need to sign in...

  • Postdoc (80%): Mitigation of Stormwater Runoff

    il y a 2 semaines

    Luxembourg, Luxembourg Springer Nature Temps plein

    Postdoc (80%): Mitigation of Stormwater Runoff:EmployerUniversity of LuxembourgLocationLuxembourgSalaryNegotiableClosing date13 May 2024Discipline Chemistry, Engineering Job Type Postdoctoral Employment - Hours Part time Duration Fixed term Qualification PhD Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob...

  • Postdoc Position in Contemporary History

    il y a 2 semaines

    Luxembourg, Luxembourg Université du Luxembourg Temps plein

    The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research in the areas of Computer...

  • Postdoctoral Researcher in The Field of

    il y a 2 semaines

    Luxembourg, Luxembourg Université du Luxembourg Temps plein

    The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research in the areas of Computer...

  • Postdoc Antenna Design/prototyping Using Additive

    il y a 2 semaines

    Luxembourg, Luxembourg Springer Nature Temps plein

    Postdoc Antenna Design/Prototyping Using Additive Manufacturing:EmployerInterdisciplinary Centre for Security, Reliability and Trust (SnT), University of LuxembourgLocationLuxembourgSalaryNegotiableClosing date15 May 2024Discipline Engineering Job Type Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You need...

  • PostDoc in Network Communications

    il y a 4 semaines

    Luxembourg, Luxembourg Université du Luxembourg Temps plein

    The University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...

  • Postdoc in Physics

    il y a 2 semaines

    Luxembourg, Luxembourg Université du Luxembourg Temps plein

    In the framework of an FNR funded project we will investigate the fundamental limitations of chalcopyrite thin film solar cells in order to improve their efficiency. Thin film solar cells provide the electricity source with the lowest greenhouse gas emissions.Your Role:The postdoc will be a member of the Department of Physics and Materials Science within the...

  • Postdoctoral Positions in Theoretical Quantum

    il y a 2 semaines

    Luxembourg, Luxembourg University of Luxembourg Temps plein

    The University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...

  • Postdoc Position in Computational Systems Biology

    il y a 2 semaines

    Luxembourg, Luxembourg Springer Nature Temps plein

    Postdoc position in computational systems biology:EmployerUniversity of LuxembourgLocationLuxembourgSalaryNegotiableClosing date25 Jun 2024Discipline Biomedicine, Life Science Job Type Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You need to sign in or create an account to a job. Job Details CompanyJob...

  • Head of Risk Management, Member of The Executive

    il y a 2 semaines

    Luxembourg, Luxembourg VP Bank (Luxembourg) SA & VP Fund Solutions (Luxembourg) SA Temps plein

    Head of Risk Management, Member of the Executive Board (M/F):Do you always go the extra mile? Are you a natural communicator, focused on clients and driven by results? Then let's work together to exceed the expectations of our clients and to continue to write the success story of VP Bank. We will give you the room you need to pursue your passion for...

  • Postdoc Joint com

    il y a 2 semaines

    Luxembourg, Luxembourg Springer Nature Temps plein

    Postdoc Joint Com &Sensing 6G Non Terrestrial Networks:EmployerInterdisciplinary Centre for Security, Reliability and Trust (SnT), University of LuxembourgLocationLuxembourgSalaryNegotiableClosing date4 Jun 2024Discipline Engineering Job Type Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You need to sign in...

  • Postdoc Fellow in

    il y a 2 semaines

    Luxembourg, Luxembourg Springer Nature Temps plein

    Postdoc Fellow in (post) quantum security of proof systems:EmployerUniversity of LuxembourgLocationLuxembourgSalaryNegotiableClosing date25 May 2024Discipline Computing, Mathematics Job Type Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You need to sign in or create an account to a job. Job Details...