Post-doctoral Fellow in Single-cell Proteomics of Neuronal Development

Il y a 2 jours
Luxembourg Luxembourg Institute of Health Temps plein
Background. Motor neuron diseases and neurodegenerative conditions such as Parkinson’s disease and Alzheimer’s disease are associated with progressive neuronal dysfunction and death, yet the molecular mechanisms underlying neurodegeneration remain poorly understood at the protein level. Patient-derived induced pluripotent stem cells (iPSCs) provide a unique window into disease-relevant biology, enabling the differentiation of human motor neurons that carry the genetic background of affected individuals. Single-cell proteomics is an emerging technology that enables quantitative protein profiling at the resolution of individual cells, capturing the cell-to-cell heterogeneity that bulk approaches inherently obscure. In this project, you will combine iPSC-derived motor neuron differentiation with state-of-the-art single-cell proteomics to dissect the protein-level landscape of neuronal development and identify disease-relevant molecular signatures at single-cell resolution. Training and Research Environment. The Proteomics of Cellular Signalling Group offers a dynamic, collaborative and genuinely international environment, with team members originating from France, Portugal, Estonia, Germany, Honduras and the United Kingdom. Embedded in the Department of Infection and Immunity, the group uses advanced mass spectrometry-based proteomics to address a broad spectrum of biological and clinical challenges, from basic signalling mechanisms to translational projects. This position sits at the intersection of stem cell biology, neuroscience, and cutting-edge single-cell proteomics, offering exceptional training in both experimental and computational aspects of modern proteomics research. You will gain hands-on experience with state-of-the-art mass spectrometry instrumentation and single-cell workflows, building a profile well suited to both academic and industry careers in the life sciences. Key Skills, Experience and Qualifications
- PhD in cell biology, neuroscience, biochemistry, or a closely related discipline.
- Hands-on experience with iPSC culture and/or neuronal differentiation protocols.
- Mass spectrometry-based proteomics and single-cell omics workflows.
- Data analysis of large single-cell omics datasets (R and/or Python).
- Languages

skills:
fluent command of English; knowledge of another language of the European Union is an asset. Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program, and opportunities for conference attendance and collaboration with other research organisations. Scientific contact Prof Dr Gunnar Dittmar In Short...:
- Contract type : Fixed-term contract (CDD)
- Contract duration : 24 months
-

Location:
rue Thomas Edison 1 A-B
- 1445 LUXEMBOURG
- Start date : 01/09/2026
- Ref : JA/PD0626/GD/CELLPRO

How to apply
: Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website.

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