Post-doctoral Researcher in The Translational Neuroscience Team at The Luxembourg Centre for Systems Biomedicine

The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character.

The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg.
We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer’s and Parkinson’s disease and their contributing factors. The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary, and together we contribute to science and society.

The Translational Neuroscience team's focus lies in the identification of new biomarkers and therapeutic targets for PD, aimed at bridging the gap between fundamental research and integrative clinical care by embedding the “from bench to bed” research approach. Fundamental research focuses on iPSC-derived neuronal models to elucidate the molecular and cellular alterations contributing to neurodegeneration in familial and idiopathic forms of PD, Dementia with Lewy bodies, atypical parkinsonism, and rare neurological diseases. Newly discovered molecular targets and disease-associated cellular phenotypes are used as readouts in drug screening approaches, to identify molecules that, after in vitro and in vivo validation, could be potentially used in future intelligent clinical trials.
- About the SIMPATHIC Project:_

The SIMPATHIC project is dedicated to optimizing drug repurposing to address unmet medical needs in rare diseases. Our novel approach involves the simultaneous development of repurposed drugs across different rare diseases with overlapping molecular and clinical characteristics. Key project objectives include:

- Developing standard operating procedures for stem cell-derived neuronal models
- Designing innovative basket clinical trials for patients with distinct genetic diagnoses but shared pathomechanisms
- Creating patient empowerment strategies to involve patient communities in drug development

**About the role...**:
**Your profile...**:
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

- Essential experience and skills:_
- You have a PhD in Neurosciences, Cell Biology or related fields
- You are experienced in working with cell-based models
- Prior experience in large-scale computational image processing and analysis
- You are experienced in coding in MATLAB or equivalent language suitable for high content imaging analysis.
- You have a proven ability to conduct research independently and to reach the project objectives (at least one publication as first author in peer-reviewed international journals)
- You have proficient communication and organizational skills, and ability to work in team
- You have an excellent knowledge of written and spoken English
- Desirable experience and skills:_
- Experience with high-throughput screening, pharmacological testing, and biomarker analysis.
- Experience in stem cell-based (especially iPSC-derived neurons) models is considered to be an advantage.
- Experience with lab automation (BeckmanCoulter SAMI software)
- Ability to conceive innovative research proposals and experience with the writing of scientific reports, publications, and grants.

**In return you will get**:

- Multilingual and international character. Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the “University of the Greater Region” (UniGR)
- A modern and dynamic university. High-quality equipment. Close ties to the business world and to the Luxembourg labour market. A unique urban site with excellent infrastructure
- A partner for society and industry. Cooperation with European institutions, innovative companies, the Financial Centre and with numerous non-academic partners such as ministries, local governments, associations, NGOs

**How to apply...**:

- Applications should include:_
- Curriculum Vitae
- Cover letter
- General information:_
- Contract Type: Fixed Term Contract 24 Month
- Work Hours: Full Time 40.0 Hours per Week
- Location: Campus Belval
- Internal Title: Postdoctoral researcher
- Job Reference: UOL07175

The yearly gross salary for every Postdoctoral Researcher at the UL is EUR 83099 (full time).