Post-doctoral Fellow in Brain Tumour Immunology

il y a 1 mois


Luxembourg Luxembourg Institute of Health Temps plein

We are seeking a Postdoctoral Fellow to join an ambitious, high-impact project unravelling the interplay between allergic inflammation and immune responses in glioblastoma (GBM). Supported by the Fond National de la Recherche and Fondation Cancer Luxembourg, this position provides the opportunity to conduct cutting-edge research in a supportive and multidisciplinary team within a multicultural research environment in the heart of Europe.

**Background & Objectives**: GBM is a devastating brain tumour with limited therapeutic options due to its highly immunosuppressive microenvironment. Recent epidemiological evidences and murine models suggest that allergic inflammation may counteract this immunosuppression and improve immune responses. Our previous work (DOI: 10.1111/all.15545) demonstrated the anti-tumoral effects of allergic inflammation in GBM. Building on this foundation, this project aims to uncover the molecular mechanisms contributing to the reversal of GBM-associated immunosuppression. The approach involves first conducting multi-omics analyses on experimental mouse models, followed by integrating these findings with existing datasets from allergy and glioma patient cohorts. These datasets have been generated by our collaborators at internationally renowned institutions, including Umeå University in Sweden (PI: Prof. Beatrice Melin) and CEU San Pablo University in Spain (PI: Prof. María Escribese).

**Key Skills, Experience and Qualifications**

**Expected**
- PhD in immunology, molecular biology, cancer biology, or a related field with a successful first postdoc (2-3 years).
- Proven expertise in mouse model experiments, with a minimum of FELASA Function A certification.
- Hands-on experience with cell culture, biochemistry, molecular biology, imaging, and flow cytometry, including data analysis.
- A strong publication record, with at least one first-author paper in a recognized international journal.
- Demonstrated time management skills, scientific rigor, and perseverance, with a self-motivated, curiosity-driven approach to research.
- Excellent writing skills, a strong sense of priority, and the ability to work effectively both independently and as part of a team.
- Fluency in English is required.

**Desirable**
- Prior experience in brain tumor immunology or metabolism would be an advantage.
- Hands-on expertise in single-cell sequencing techniques such as CITE-seq.
- Knowledge of bioinformatics approaches and experience with programming languages like R or Python.
- Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as opportunities for conference attendance and collaborations with
- other research organizations.

**Scientific contact**
Dr Aurélie Poli

**In Short...**:

- Location : rue Nicolas-Ernest Barblé 6 - 1210 Luxembourg
- Start date : 01/04/2025
- Ref : JA/PD1124/AP/NIG

**How to apply**:
Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website.



  • Luxembourg Luxembourg Institute of Health Temps plein

    **Within the Department of Precision Health, Dr. Torsten Bohn, Head of the Nutrition & Health Research Group (NUTRIHEALTH), and his team aim to explore dietary patterns, their nutrient and non-nutrient composition, and their association with chronic conditions such as metabolic syndrome. An important focus of the group is examining the relationship between...


  • Luxembourg Luxembourg Institute of Health Temps plein

    **Background**:Parkinson’s disease is a progressive neurological disease that affects especially the older population. One hallmark of the disease is the loss of dopaminergic neurons in the midbrain. While other causes of Parkinson’s disease are still unclear, the loss of mitochondrial functions is a key feature of the disease. A key molecule for the...


  • Luxembourg Université du Luxembourg Temps plein

    The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The Faculty of Science, Technology and Medicine (FSTM) at the University of Luxembourg contributes multidisciplinary expertise in the fields of Mathematics, Physics, Engineering, Computer Science, Life Sciences and...

  • Post-doctoral Fellow in

    Il y a 6 mois


    Luxembourg Université du Luxembourg Temps plein

    The** University of Luxembourg** is an **international research** university with a distinctly **multilingual** and **interdisciplinary** character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary centres focus on research in the...

  • Post-doctoral Fellow in

    Il y a 6 mois


    Luxembourg University of Luxembourg Temps plein

    **The University | About us...** The** University of Luxembourg** is an **international research** university with a distinctly **multilingual** and **interdisciplinary** character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary...


  • Luxembourg Luxembourg Institute of Health Temps plein

    **The Physical Activity, Sport and Health (PASH)** research group aims to improve knowledge on the beneficial effects of physical activity on individuals’ health with and without disease and of any age, as well as on the mechanisms leading to the development of sports injury.** **Dr. **Laurent Malisoux**, PhD, Head of this research group, is seeking a...


  • Luxembourg Luxembourg Institute of Health Temps plein

    **OBJECTIVES** In partnership with several pharma companies, our group focuses on defining targets or pathways in the tumor microenvironment that are involved in impairing the anti-tumor immune response and compromising the effect of ICIs. Our aim is to develop innovative molecules that can be combined with ICIs to improve/extend their benefit and to...


  • Luxembourg Luxembourg Institute of Health Temps plein

    Within the Department of Precision Health, Dr. Torsten Bohn, Head of the Nutrition & Health Research Group (NUTRIHEALTH), aims, in collaboration with his team, to explore dietary patterns, their (non)nutrient composition and association to chronic conditions, e.g. metabolic syndrome and related aspects. An important focus is the relation of diet to public...


  • Luxembourg Université du Luxembourg Temps plein

    The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine -...


  • Luxembourg Université du Luxembourg Temps plein

    The Department of the Faculty of Law, Economics and Finance of the University of Luxembourg is looking for a Postdoctoral researcher to conduct research in the business and management field. **Your Role...**: The postdoctoral researcher will be working under the supervision of Professor Denise Fletcher. The Postdoctoral Researcher will be responsible...


  • Luxembourg University of Luxembourg Temps plein

    **Your Role...** The postdoctoral researcher will be working under the supervision of Professor Denise Fletcher. The Postdoctoral Researcher will be responsible for: - Publication of articles in scientific articles and contributions to conferences in the management field - Assisting with curriculum design, teaching activities, (one to three hours a week),...


  • Luxembourg Université du Luxembourg Temps plein

    The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine -...


  • Luxembourg Université du Luxembourg Temps plein

    The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The Faculty of Law, Economics and Finance (FDEF) at the University of Luxembourg offers a unique academic and research environment. Rooted in Luxembourg but with a European and international outlook, teaching and research...


  • Luxembourg Luxembourg Institute of Health Temps plein

    **PROJECT** **Scientific contacts** **KEY ACCOUNTABILITIES** - Set up the project, manage sample processing - Conduct wet-lab experiments, optimize biomarker analysis, run cfDNA isolation and sequencing - Participate in data analysis and model generation - depending on individual agreement - Publish results in scientific journals and/or file patents if...


  • Luxembourg Luxembourg Institute of Health Temps plein

    **Background**: Personalisation of care is expected to improve short and long term outcomes of people living with diabetes. Precision health strategies can be defined as the right intervention/ treatment/ care for the right person at the right time. One way to achieve this ambitious objective is to rely on deep digital phenotyping methods leading to the...


  • Luxembourg Université du Luxembourg Temps plein

    The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The Faculty of Law, Economics and Finance (FDEF) at the University of Luxembourg offers a unique academic and research environment. Rooted in Luxembourg but with a European and international outlook, teaching and research...


  • Luxembourg Université du Luxembourg Temps plein

    The** University of Luxembourg** is an **international research** university with a distinctly **multilingual** and **interdisciplinary** character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary centres focus on research in the...

  • Doctoral Researcher

    il y a 2 semaines


    Luxembourg Université du Luxembourg Temps plein

    The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The Faculty of Law, Economics and Finance (FDEF) at the University of Luxembourg offers a unique academic and research environment. Rooted in Luxembourg but with a European and international outlook, teaching and research...

  • Doctoral Researcher

    Il y a 6 mois


    Luxembourg Université du Luxembourg Temps plein

    **Your Role...**: The doctoral researcher will benefit from being part of large research group comprising several PhDs and Postdoctoral Researchers working on related topics of Urban Economics, Trade and Migration. Being part of the project will allow the doctoral researcher to enhance his/her knowledge-base and experience; working on the various aspects of...

  • Doctoral Researcher

    Il y a 6 mois


    Luxembourg Université du Luxembourg Temps plein

    **Your Role...**: The doctoral researcher will benefit from being part of large research group comprising several PhDs and Postdoctoral Researchers working on related topics of Human Rights, Criminal Law, Social Justice. Being part of the project will allow the doctoral researcher to enhance his/her knowledge-base and experience; working on the various...