![Luxembourg Institute of Health](https://media.trabajo.org/img/noimg.jpg)
Post-doctoral Fellow in Brain Tumor Metabolism:
il y a 3 semaines
**Background. **In this interdisciplinary project, we aim to investigate treatment resistance mechanisms in Glioblastoma (GBM), the most aggressive and incurable brain tumour. GBM cells display very strong intrinsic plasticity and adapt their energy production to support tumor growth and survive versatile microenvironments. We will investigate how the tumor cells adapt their metabolic demands during tumor growth and upon treatment. We will focus in particular on the function of mitochondria, the organelles supporting energy production in the cells. Metabolic features of glioblastoma will be compared to other brain tumor entities, including brain metastases.
**Objectives.** We are looking for a molecular biologist with strong expertise in metabolomics and LC-MS data analysis to conduct functional cancer assays and metabolomics profiling.
**Training and research environment.** NORLUX lab is a multinational and interdisciplinary team focusing on the biology of malignant brain tumours. The team is a part of the Department of Cancer Research and use state-of-the-art preclinical models combined with cutting-edge molecular technologies and machine learning tools. The post-doctoral fellow will be supported through an FNR INTER funded project established as an international collaboration with the Institute of Biotechnology CAS, Vestec, Czech Republic (PIs: Renata Zobalova and Jiri Neuzil). Post-doc will join an interdisciplinary project team, including biologists, animal experts and bioinformaticians. The project will be carried out in collaboration with the LIH’s Metabolomics platform (Head: Nathalie Legrave) and the Cancer Metabolism Group (PI: Johannes Meiser).
**Key Skills, Experience and Qualifications**
- PhD in molecular biology, metabolomics or a related field.
- Expertise in computational and statistical analysis of LC-MS data for targeted and untargeted data processing approaches, stable isotope labelling incorporation and metabolic flux analyses is required. Experience in metabolomics data analysis and statistics tools and software such as TraceFinder, MetaboAnalyst, Compound
- Discoverer and SIMCA is desirable.
- Prior experience in cancer research, functional assay or drug testing is an asset.
- Understanding of common bioinformatics approaches and experience with programming languages for data analysis (R, Python) is a plus.
- Independent and self-motivated person, scientific creativity and originality, strong team spirit and collaborative capacity, excellent time management, rigour, perseverance, strong writing skills.
- Fluency in English is mandatory.
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as opportunities for conference attendance and collaborations with other research organisations.
Scientific contact
Dr Anna Golebiewska
**In Short...**:
- Contract type : Fixed-term contract (CDD)
- Contract duration : 24 months
- Location : rue Nicolas-Ernest Barblé 6 - 1210 Luxembourg
- Start date : 01/10/2024
- Ref : JA/PD0624/AG/NORLUX
**How to apply**:
Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website.
-
Post-doctoral Fellow in Brain Tumor Metabolism:
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinBackground. In this interdisciplinary project, we aim to investigate treatment resistance mechanisms in Glioblastoma (GBM), the most aggressive and incurable brain tumour. GBM cells display very strong intrinsic plasticity and adapt their energy production to support tumor growth and survive versatile microenvironments. We will investigate how the tumor...
-
Post-doctoral Fellow in Cancer Metabolism
il y a 3 jours
Luxembourg Luxembourg Institute of Health Temps plein**PROJECT** During the last two decades, the importance of metabolism to support cancer onset and progression has gained increasing attention. Among the various nutrients that support cancer cell metabolism, serine has emerged as a very important one. Serine is not only an important precursor for anabolic metabolism (i.e. nucleotide synthesis) but also...
-
Post-doctoral Fellow in Cancer Metabolism
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinPROJECTDuring the last two decades, the importance of metabolism to support cancer onset and progression has gained increasing attention. Among the various nutrients that support cancer cell metabolism, serine has emerged as a very important one. Serine is not only an important precursor for anabolic metabolism (i.e. nucleotide synthesis) but also supports...
-
Post-doctoral Fellow in Cancer Research
il y a 3 semaines
Luxembourg Springer Nature Temps plein**Post-Doctoral Fellow in Cancer Research**: - Employer- Luxembourg Institute of Health (LIH)- Location- Luxembourg (LU)- Salary- N/A- Closing date- 13 Apr 2024- Discipline Life Science Job Type Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You need to sign in or create an account to a...
-
Post-doctoral Fellow in Cancer Research
il y a 3 jours
Luxembourg Luxembourg Institute of Health Temps plein**BACKGROUND** Chronic Lymphocytic Leukemia (CLL) represents the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly incurable disease. This cancer is characterized by an accumulation of abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid organs of the patients. CLL progression is highly dependent...
-
Post-doctoral Fellow in Cancer Research
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinBACKGROUNDChronic Lymphocytic Leukemia (CLL) represents the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly incurable disease. This cancer is characterized by an accumulation of abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid organs of the patients. CLL progression is highly dependent on...
-
Post-doctoral Fellow in
il y a 2 semaines
Luxembourg, Luxembourg University of Luxembourg Temps pleinThe University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...
-
Post-doctoral Fellow in Pharmacoepidemiology or
il y a 3 semaines
Luxembourg Luxembourg Institute of Health Temps pleinThe Ageing, Cancer, and Disparities (ACADI) Research Unit within the Department of Precision Health, is an international and multidisciplinary team which aims to improve cancer outcomes in older adults by targeting key moments in the cancer journey where inequalities are likely to occur: before diagnosis, during the treatment decision-making process, and the...
-
Post-doctoral Fellow in Mathematics
il y a 4 semaines
Luxembourg Springer Nature Temps plein**Post-Doctoral Fellow in Mathematics (Statistics)**: - Employer- University of Luxembourg- Location- Luxembourg, Esch-sur-Alzette- Salary- Negotiable- Closing date- 12 May 2024- Discipline Mathematics Job Type Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You need to sign in or create an account...
-
Technical Expert in Cancer Metabolism
il y a 3 jours
Luxembourg Luxembourg Institute of Health Temps pleinIn recent years, we have revealed that the small metabolite formate promotes cancer cell invasion and metastasis. We know today that formate concentrations within the tumor microenvironment are often increased providing a pro-metastatic environment. To continue in unravelling the role of formate in context of cancer metastasis we are seeking a skilled and...
-
Post-doctoral Fellow in
il y a 2 semaines
Luxembourg Université du Luxembourg Temps pleinThe** University of Luxembourg** is an **international research** university with a distinctly **multilingual** and **interdisciplinary** character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary centres focus on research in the...
-
Senior Post-doctoral Fellow in Immuno-oncology
il y a 3 jours
Luxembourg Luxembourg Institute of Health Temps plein**OBJECTIVES** In partnership with several pharma companies, our group focuses on defining targets or pathways in the tumor microenvironment that are involved in impairing the anti-tumor immune response and compromising the effect of ICIs. Our aim is to develop innovative molecules that can be combined with ICIs to improve/extend their benefit and to...
-
Post-doctoral Fellow in
il y a 2 semaines
Luxembourg University of Luxembourg Temps plein**The University | About us...** The** University of Luxembourg** is an **international research** university with a distinctly **multilingual** and **interdisciplinary** character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University’s faculties and interdisciplinary...
-
Technical Expert in Cancer Metabolism
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinIn recent years, we have revealed that the small metabolite formate promotes cancer cell invasion and metastasis. We know today that formate concentrations within the tumor microenvironment are often increased providing a pro-metastatic environment. To continue in unravelling the role of formate in context of cancer metastasis we are seeking a skilled and...
-
Post-doctoral Fellow in Digital Health
il y a 2 semaines
Luxembourg Luxembourg Institute of Health Temps plein**The Physical Activity, Sport and Health (PASH)** research group aims to improve knowledge on the beneficial effects of physical activity on individuals’ health with and without disease and of any age, as well as on the mechanisms leading to the development of sports injury.** **Dr. **Laurent Malisoux**, PhD, Head of this research group, is seeking a...
-
Doctoral researcher in Computational Biology and Metabolism
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinAbout us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in...
-
Doctoral researcher in Computational Biology and Metabolism
il y a 4 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinAbout us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in...
-
Doctoral researcher in Computational Biology and Metabolism
il y a 4 semaines
Luxembourg (Canton), Luxembourg Université du Luxembourg Temps pleinAbout us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in...
-
Laboratory Technician
il y a 4 semaines
Luxembourg Luxembourg Institute of Health Temps pleinThe NORLUX Neuro-Oncology Laboratory at the Department of Cancer Research is recruiting a full-time laboratory technician. The lab focuses on the biology of malignant brain tumors with an emphasis on tumor plasticity, tumor-host interactions and tumor metabolism. The team has developed unique patient-based 3D tumor organoid cultures and patient-derived...
-
Laboratory Technician
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinThe NORLUX Neuro-Oncology Laboratory at the Department of Cancer Research is recruiting a full-time laboratory technician. The lab focuses on the biology of malignant brain tumors with an emphasis on tumor plasticity, tumor-host interactions and tumor metabolism. The team has developed unique patient-based 3D tumor organoid cultures and patient-derived...