![Luxembourg Institute of Health](https://media.trabajo.org/img/noimg.jpg)
Post-doctoral Fellow in Brain Tumor Metabolism:
il y a 2 semaines
Background. In this interdisciplinary project, we aim to investigate treatment resistance mechanisms in Glioblastoma (GBM), the most aggressive and incurable brain tumour. GBM cells display very strong intrinsic plasticity and adapt their energy production to support tumor growth and survive versatile microenvironments. We will investigate how the tumor cells adapt their metabolic demands during tumor growth and upon treatment. We will focus in particular on the function of mitochondria, the organelles supporting energy production in the cells. Metabolic features of glioblastoma will be compared to other brain tumor entities, including brain metastases.
Objectives. We are looking for a molecular biologist with strong expertise in metabolomics and LC-MS data analysis to conduct functional cancer assays and metabolomics profiling.
Training and research environment. NORLUX lab is a multinational and interdisciplinary team focusing on the biology of malignant brain tumours. The team is a part of the Department of Cancer Research and use state-of-the-art preclinical models combined with cutting-edge molecular technologies and machine learning tools. The post-doctoral fellow will be supported through an FNR INTER funded project established as an international collaboration with the Institute of Biotechnology CAS, Vestec, Czech Republic (PIs: Renata Zobalova and Jiri Neuzil). Post-doc will join an interdisciplinary project team, including biologists, animal experts and bioinformaticians.
The project will be carried out in collaboration with the LIH's Metabolomics platform (Head:
Nathalie Legrave) and the Cancer Metabolism Group (PI: Johannes Meiser).
Key Skills, Experience and Qualifications
- PhD in molecular biology, metabolomics or a related field.
- Expertise in computational and statistical analysis of LC-MS data for targeted and untargeted data processing approaches, stable isotope labelling incorporation and metabolic flux analyses is required. Experience in metabolomics data analysis and statistics tools and software such as TraceFinder, MetaboAnalyst, Compound
- Discoverer and SIMCA is desirable.
- Prior experience in cancer research, functional assay or drug testing is an asset.
- Understanding of common bioinformatics approaches and experience with programming languages for data analysis (R, Python) is a plus.
- Independent and selfmotivated person, scientific creativity and originality, strong team spirit and collaborative capacity, excellent time management, rigour, perseverance, strong writing skills.
- Fluency in English is mandatory.
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as opportunities for conference attendance and collaborations with other research organisations.
Dr Anna Golebiewska
In Short
:
- Contract type : Fixedterm contract (CDD)
- Contract duration : 24 months
- Location : rue Nicolas-Ernest Barblé Luxembourg
- Start date : 01/10/2024
- Ref : JA/PD0624/AG/NORLUX
How to apply:
Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website.
-
Post-doctoral Fellow in Cancer Metabolism
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinPROJECTDuring the last two decades, the importance of metabolism to support cancer onset and progression has gained increasing attention. Among the various nutrients that support cancer cell metabolism, serine has emerged as a very important one. Serine is not only an important precursor for anabolic metabolism (i.e. nucleotide synthesis) but also supports...
-
Post-doctoral Fellow in Cancer Research
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinBACKGROUNDChronic Lymphocytic Leukemia (CLL) represents the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly incurable disease. This cancer is characterized by an accumulation of abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid organs of the patients. CLL progression is highly dependent on...
-
Post-doctoral Fellow in
il y a 2 semaines
Luxembourg, Luxembourg University of Luxembourg Temps pleinThe University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...
-
Technical Expert in Cancer Metabolism
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinIn recent years, we have revealed that the small metabolite formate promotes cancer cell invasion and metastasis. We know today that formate concentrations within the tumor microenvironment are often increased providing a pro-metastatic environment. To continue in unravelling the role of formate in context of cancer metastasis we are seeking a skilled and...
-
Doctoral researcher in Computational Biology and Metabolism
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinAbout us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in...
-
Doctoral researcher in Computational Biology and Metabolism
il y a 4 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinAbout us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in...
-
Laboratory Technician
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinThe NORLUX Neuro-Oncology Laboratory at the Department of Cancer Research is recruiting a full-time laboratory technician. The lab focuses on the biology of malignant brain tumors with an emphasis on tumor plasticity, tumor-host interactions and tumor metabolism. The team has developed unique patient-based 3D tumor organoid cultures and patient-derived...
-
Post-doctoral Fellow in Nutrition/public Health
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinWithin the Department of Precision Health, Dr. Torsten Bohn, Head of the Nutrition & Health Research Group (NUTRIHEALTH), aims, in collaboration with his team, to explore dietary patterns, their (non)nutrient composition and association to chronic conditions, e.g. metabolic syndrome and related aspects. An important focus is the relation of diet to public...
-
Postdoctoral Researcher in Brain Organoids
il y a 2 semaines
Luxembourg, Luxembourg Springer Nature Temps pleinPostdoctoral researcher in Brain Organoids Technologies:EmployerLCSB Luxembourg Centre for Systems BiomedicineLocationLuxembourgSalaryNegotiableClosing date11 Jun 2024Discipline Biomedicine, Health Science, Life Science Job Type Bioinformatician, Engineer, Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You...
-
Postdoc Fellow in
Il y a 2 mois
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...
-
Postdoc Fellow in
il y a 4 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe University | About us...The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research...
-
Postdoc Fellow in
il y a 2 semaines
Luxembourg, Luxembourg Springer Nature Temps pleinPostdoc Fellow in (post) quantum security of proof systems:EmployerUniversity of LuxembourgLocationLuxembourgSalaryNegotiableClosing date25 May 2024Discipline Computing, Mathematics Job Type Postdoctoral Employment - Hours Full time Duration Fixed term Qualification PhD Sector Academia- You need to sign in or create an account to a job. Job Details...
-
Postdoctoral researcher in Brain Organoids Technologies
Il y a 2 mois
Luxembourg, Luxembourg Université du Luxembourg Temps pleinAbout us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in...
-
Postdoctoral researcher in Brain Organoids Technologies
il y a 4 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinAbout us...The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in...
-
Doctoral Researcher in Computational Biology and
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and _in silico_. We focus on neurodegenerative processes and are especially interested in Alzheimer's and...
-
Phd Student: Nanopore Sequencing-based
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinPROJECTWe are looking for a curious, agile and committed PhD student to join the NANO-SCOPE project, funded by FNR CORE.Brain and central nervous system (CNS) tumors are rare and heterogeneous, with gliomas having a poor prognosis. The current gold standard for diagnosis is invasive and time-consuming. Liquid biopsies, such as cell-free DNA (cfDNA) from...
-
Internship Position in Leukemia Research
il y a 2 semaines
Luxembourg, Luxembourg Luxembourg Institute of Health Temps pleinBACKGROUNDChronic Lymphocytic Leukemia (CLL) represent the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly incurable disease. This cancer is caracterized by an accumulation of abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid organs of the patients. CLL progression is highly dependent on...
-
Post-doctoral Researcher
il y a 2 semaines
Luxembourg, Luxembourg University of Luxembourg (L) Temps pleinContract Type: Fixed Term ContractDuration: 24 MonthPost-doctoral researcher in neuro-cognitive research on numeracy and literacyThe University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000...
-
Post-doctoral Fellow in Nursing Science
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research in the areas of Computer...
-
Post-doctoral Researcher in Neuro-cognitive
il y a 2 semaines
Luxembourg, Luxembourg Université du Luxembourg Temps pleinThe University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 students and more than 2,000 employees from around the world. The University's faculties and interdisciplinary centres focus on research in the areas of Computer...