Postdoctoral Researcher On Cellular Alzheimer
il y a 3 jours
The **Luxembourg Centre for Systems Biomedicine (LCSB)** is an interdisciplinary research centre of the University of Luxembourg. We conduct fundamental and translational research in the field of Systems Biologyand Biomedicine - in the lab, in the clinic and _in silico_. We focus on neurodegenerative processes and are especially interested in Alzheimer’s and Parkinson’s disease and their contributing factors.
The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary and together we contribute to science and society.
**Your Role...**:
The open position is part of the recently received a PEARL grant from the Fonds National de la Recherche in Luxembourg to study the role of microglia and tunneling nanotubes networks connecting microglia to neurons in Alzheimer’s disease.
The MINIALZ PEARL project aims to study the interaction of immune cells and neurons in the brain and to identify molecular mechanisms that can be harnessed for developing preventive, disease-modifying or acute therapeutic measures. MINIALZ will further identify early immune function and biomarker traits, in order to support diagnosis prior to clinical appearance. MINIALZ will be based on a new mechanism recently identified by the applicant’s group, by which microglia form a tunnelling nanotube network (TNTs) with neighboring neurons in order to free the latter from pathological proteins and ensure their function and survival. Preliminary data suggest that such microglia-neuron TNTs may contribute to neuronal survival in models of neurodegeneration and the involved mechanisms are defective in microglia carrying disease-associated AD risk mutations.
- You will study the role and formation of TNTs in iPSC derived neurons and microglia and will further elucidate the underlying mechanisms by generating and studying lines with various mutations identified in previous GWAS studies
- You will be closely collaborating with the other post-docs, PhD students and technicians involved in this large project
**What we expect from you**:
- PhD in neurobiology, biophysics, neuroimmunology or related scientific/technical discipline
- Experience with generating iPSCs, with primary cell culture as well as with neuronal and microglia cultures.
- Advanced microscopy skills
- Previous experience in working with Alzheimer’s disease models is considered a plus
- Standard molecular biology techniques
- Highly reliable and precise working style
- Further career development by writing own grants will be strongly supported
- Communication in English is essential, both written and spoken
**Here’s what awaits you at the LCSB...**:
- **Excellent work environment** with state-of-the-art infrastructure, laboratory and administrative support
- **Truly connected. **We work together with hospitals and research institutes on a national and international level as well as industrial partners. Connection between science and society is very important to us. From our school lab - the Scienteens Lab - to the different outreach activities and collaborative partnerships with patient associations, we love to listen to society’s needs and share our passion for science
- **Be part of a multicultural team. **At the LCSB we have more than 50 nationalities. Throughout the year, we organise team-building events, networking activities and more
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