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We are seeking a Postdoctoral Fellow to join an ambitious, high-impact project unravelling the interplay between allergic inflammation and immune responses in glioblastoma (GBM). Supported by the Fond National de la Recherche and Fondation Cancer Luxembourg, this position provides the opportunity to conduct cutting-edge research in a supportive and multidisciplinary team within a multicultural research environment in the heart of Europe.
**Background & Objectives**: GBM is a devastating brain tumour with limited therapeutic options due to its highly immunosuppressive microenvironment. Recent epidemiological evidences and murine models suggest that allergic inflammation may counteract this immunosuppression and improve immune responses. Our previous work (DOI: 10.1111/all.15545) demonstrated the anti-tumoral effects of allergic inflammation in GBM. Building on this foundation, this project aims to uncover the molecular mechanisms contributing to the reversal of GBM-associated immunosuppression. The approach involves first conducting multi-omics analyses on experimental mouse models, followed by integrating these findings with existing datasets from allergy and glioma patient cohorts. These datasets have been generated by our collaborators at internationally renowned institutions, including Umeå University in Sweden (PI: Prof. Beatrice Melin) and CEU San Pablo University in Spain (PI: Prof. María Escribese).
**Key Skills, Experience and Qualifications**
**Expected**
- PhD in immunology, molecular biology, cancer biology, or a related field with a successful first postdoc (2-3 years).
- Proven expertise in mouse model experiments, with a minimum of FELASA Function A certification.
- Hands-on experience with cell culture, biochemistry, molecular biology, imaging, and flow cytometry, including data analysis.
- A strong publication record, with at least one first-author paper in a recognized international journal.
- Demonstrated time management skills, scientific rigor, and perseverance, with a self-motivated, curiosity-driven approach to research.
- Excellent writing skills, a strong sense of priority, and the ability to work effectively both independently and as part of a team.
- Fluency in English is required.
**Desirable**
- Prior experience in brain tumor immunology or metabolism would be an advantage.
- Hands-on expertise in single-cell sequencing techniques such as CITE-seq.
- Knowledge of bioinformatics approaches and experience with programming languages like R or Python.
- Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as opportunities for conference attendance and collaborations with
- other research organizations.
**Scientific contact**
Dr Aurélie Poli
**In Short...**:
- Location : rue Nicolas-Ernest Barblé 6 - 1210 Luxembourg
- Start date : 01/04/2025
- Ref : JA/PD1124/AP/NIG
**How to apply**:
Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website.
