Phd Student in Cancer Research

il y a 2 semaines


Luxembourg Luxembourg Institute of Health Temps plein

**Background**

The immune system plays a pivotal role in identifying and eradicating cancer cells. Cytotoxic lymphocytes employ a specialized cell-to-cell interface known as the immunological synapse (IS) to effectively eliminate their targets. Recently, our research group has made a significant breakthrough by demonstrating that cancer cells can evade natural killer (NK) cell-mediated cytotoxicity by polarizing their actin cytoskeleton towards the IS. Our group's mission is to delve deeper into the molecular mechanisms underlying this phenomenon and to translate our findings into actionable strategies aimed at restoring a potent anti-tumor immune response.

**PhD student project**

**Related references**
- Al Absi et al. Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity. Cancer Res. 2018;78(19):5631-43.
- Wurzer et al. Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling. Front Immunol. 2021;12:619069.
- Ockfen et al. Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both? Front Immunol. 2023;14:1276602.

**Key Skills, Experience and Qualifications**

**How to apply**

**Contact**
Clément Thomas, PhD
Group Leader, Cytoskeleton and Cancer Progression
Luxembourg Institute of Health
Department of Cancer Research

**Gender Equality**

The LIH is an equal opportunities employer. We are fully committed to removing any discriminatory barrier related to gender, and not only, in recruitment and career progression of our staff. The LIH is attentive to gender representation among its leadership staff and aims to eliminate obstacles to the recruitment and promotion of female leaders and their career development.

**In Short...**:

- Contract type : Fixed-term contract (CDD)
- Contract duration : 36 months
- Work hours : 40h/week
- Location : rue Nicolas-Ernest Barblé 6 - 1210 Luxembourg
- Start date : ASAP
- Ref : MC/PhDCCP0224/CT/CCP

**How to apply**:
Applications including a letter detailing your motivation and a curriculum vitae should be sent through our website.


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